Mathematical and Physical Modeling of Actin Dynamics in Motile Cells
نویسندگان
چکیده
Mathematical modeling has been very instrumental in aiding traditional experimental methods in uncovering the mysteries of actin dynamics. Here we review recent quantitative models of actin dynamics focusing on ATP hydrolysis effects, force generation by single actin filaments and networks, self-organization and dynamics of actin networks, dynamics of lamellipodia, filopodia and lamella, and integrative mechanochemistry of whole motile cells. We discuss both modeling methods and specific insights from modeling that helped answering biological questions. Abbreviations ADP adenosine diphosphate ATP adenosine triphosphate BR Brownian ratchet CCA cofilin, coronin, and Aip1 CP capping protein F-actin filamentous or polymerized actin G-actin globular or unpolymerized actin
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